Abstract
#Bromodomains
are #protein domains that recognize acetylated lysine residues and are
important for recruiting a large number of #protein and #multiprotein complexes
to sites of lysine acetylation. They play an important role in chromatin
biology and are popular targets for #drugdiscovery. Compound screening in this
area requires the use of #biochemical assays to assess the binding potency of #potentialdrug
candidates. Foremost among the efforts to target bromodomains are those aimed
at identifying compounds that interact with the bromodomain and extra-terminal
domain (BET) family of bromodomain-containing proteins (BRD2, BRD3, BRD4, and
BRDT). Inhibitors of these #proteins are under clinical development for a large
variety of #oncologic indications
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