Evidence-Based Valuation in #Oncology:: Lessons Learned from a #Case Study

Abstract

BACKGROUND:

Value demonstration in health care remains a challenge. This paper examines traditional approaches to pricing and the evolution of value-based pricing (VBP), and proposes a new framework for evidence-based valuation (EBV). The main objective of EBV is to estimate the value-based pricing range for the new medicine, identify key product attributes that drive value as perceived by various stakeholders, and then elucidate the requisite evidence to support those value claims.

#Radiotherapy for recurrent #prostate cancer: 2018 Recommendations of the #Australian and #New Zealand #Radiation Oncology #Genito Urinary group

.

Abstract

The management of #patients with #biochemical, local, nodal, or #oligometastatic relapsed #prostatecancer has become more challenging and controversial. Novel imaging modalities designed to detect recurrence are increasingly used, particularly PSMA-PET scans in #Australia, #NewZealand and some #Europeancountries. Imaging techniques such as MRI and PET scans using other #prostatecancer-specific tracers are also being utilised across the #world. The optimal timing for commencing salvage treatment, and the role of local and/or systemic therapies remains controversial

A national survey of AIRO (#ItalianAssociationofRadiationOncology) brachytherapy (#InterventionalRadiotherapy) study group

Abstract

PURPOSE: To review #brachytherapy resources and to explore current practice patterns in #Italy.

MATERIAL AND METHODS: In 2016, on behalf of the Italian Association of #RadiationOncology (AIRO), the Brachytherapy Study Group proposed conducting a survey in order to identify brachytherapy practice patterns. An electronic questionnaire was sent to all #radiotherapy centres in #Italy, asking for: 1. General information on the #RadiationOncology Centre (affiliation, whether brachytherapy was delivered or not); 2. Brachytherapy equipment and human resources; 3. Brachytherapy procedures; 4. Brachytherapy assessment (number of patients treated annually, treated sites, and different modalities of treatments

Binding Assays for #BromodomainProteins: Their Utility in #DrugDiscovery in #Oncology and #InflammatoryDisease

Abstract

#Bromodomains are #protein domains that recognize acetylated lysine residues and are important for recruiting a large number of #protein and #multiprotein complexes to sites of lysine acetylation. They play an important role in chromatin biology and are popular targets for #drugdiscovery. Compound screening in this area requires the use of #biochemical assays to assess the binding potency of #potentialdrug candidates. Foremost among the efforts to target bromodomains are those aimed at identifying compounds that interact with the bromodomain and extra-terminal domain (BET) family of bromodomain-containing proteins (BRD2, BRD3, BRD4, and BRDT). Inhibitors of these #proteins are under clinical development for a large variety of #oncologic indications

Phase II evaluation of dalantercept in the treatment of persistent or recurrent epithelial #ovariancancer: An NRG #Oncology/#GynecologicOncology Group study

.

Abstract

OBJECTIVE: To determine the efficacy of dalantercept, a soluble ALK1 inhibitor receptor fusion protein, in #patients with persistent or recurrent #ovariancarcinoma and related #malignancies.

METHODS: Eligibility criteria included measurable disease, 1-2 prior cytotoxic regimens and GOG performance status (PS) ≤2. Dalantercept was administered subcutaneously at 1.2 mg/kg every 3 weeks until disease progression or development of unacceptable #toxicity. The primary null hypothesis was the probability of response ≤0.10 and the probability of 6-month progression-free survival without receipt of non-protocol therapy (event-free survival at 6 months, EFS6) ≤0.15, using RECIST 1.1 criteria

Utilisation of #geriatric assessment in #oncology - a survey of #Australian #medicaloncologists

Abstract

INTRODUCTION:

#Geriatric assessment (GA) is a multidimensional health assessment of the older person to evaluate their physical and cognitive function, comorbidities, #nutrition, #medications, psychological state, and social supports. GA may help #oncologists optimise care for older patients with #cancer. The aim of this study was to explore the views of #Australian #medicaloncologists regarding the incorporation of geriatric screening tools, GA and collaboration with geriatricians into routine #clinicalpractice.

METHODS:

Members of the #MedicalOncology Group of #Australia were invited to complete an online survey that evaluated respondent demographics, practice characteristics, treatment decision-making factors, use of GA, and access to #geriatricians.

The European Society of Gynaecological Oncology/European Society for Radiotherapy and Oncology/European Society of Pathology Guidelines for the Management of Patients with Cervical Cancer

.

Abstract

Regrettably, the author metadata used for the previous correction (doi: https://doi.org/10.1007/s00428-018-2380-7 ) contained an error in the tagging of W. Glenn McCluggage's name; this has been corrected. No further adjustments have been made to the Correction, or the original Guideline paper (doi: https://doi.org/10.1007/s00428-018-2362-9 ).

Use and perception of complementary and #alternativemedicine among #cancer patients: the CAMEO-PRO study : Complementary and alternative medicine in #oncology

Abstract

BACKGROUND:

It is estimated that about half of #cancerpatients use at least one form of complementary and #alternativemedicines (CAM) in their life but there is a strong reticence of #patients in talking about CAM with their #oncologist. Primary aim of this study was to inform patients about CAM, focusing on their supposed benefits, toxicities and interactions with conventional #therapeuticagents. The study also explored patients' perception about CAM and ascertained the level of CAM use among #cancer patients of an #Italian academic hospital

Limits of surgery in #uro-oncology

Abstract

The limits of #cancersurgery in uro-oncology are characterized by a carefully weighed risk of #surgical feasibility and #oncological necessity. The limits of uro-oncological #cancer surgery do not represent fixed dogmas but ideally these more or less cognitive boundaries move based on new scientific findings, improved imaging modalities, optimized #surgicaltechniques and #perioperativecare

Advance-care-planning (ACP) documentation strategies; Goals-of-Care (GOC) as an alternative to Not-for-Resuscitation (NFR) in #medical and #oncology patients. A pre-and-post controlled study on quantifiable outcomes

Abstract

BACKGROUND: Health services in #Tasmania, #Victoria and now Western #Australia are changing to goals-of-care (GOC) advance-care-planning (ACP) documentation strategies.

AIM: To compare the #clinicalimpact of two different health department sanctioned ACP documentation strategies.

METHODS: An unblinded, pre-and-post, controlled study over two corresponding six-month periods in 2016 and 2017 comparing the current discretional not-for-resuscitation (NFR) with a new, inclusive GOC strategy in two medical/#oncology wards at a large private hospital. Main outcomes were the uptake of ACP forms per #hospitalisation and the timing between hospital admission, ACP form completion, and in-patient death. Secondary outcomes included utilisation of the rapid response team (RRT), #palliative and critical care services

Overview of Precision Oncology Trials: Challenges and Opportunities.

Abstract

Introduction In recent years, the therapeutic management of selected #patients with #cancer has shifted towards the '#Precision Medicine" approach based on patient's mechanisms of #tumorigenesis, and their baseline characteristics and #comorbidities. Complete #tumor and cell-free #DNA profiling using #nextgenerationsequencing, #proteomic and #RNA analysis, and #immune mechanisms should to be taken into consideration and accurate #bioinformatic analysis is essential to optimize patient's treatment. Areas covered The challenges and opportunities of conducting #clinicaltrials in precision #oncology are summarized

Second opinions in #orthopediconcology imaging: can fellowship training reduce clinically significant discrepancies?

Second opinions in #orthopediconcology imaging: can fellowship training reduce clinically significant discrepancies?

Responses to the 2017 '1 Million Gray Question': ASTRO membership's opinions on the most important research question facing #radiationoncology

Responses to the 2017 '1 Million Gray Question': ASTRO membership's opinions on the most important research question facing #radiationoncology

Sex Differences in Efficacy and #Toxicity of Systemic Treatments: An Undervalued Issue in the Era of #PrecisionOncology

Sex Differences in Efficacy and #Toxicity of Systemic Treatments: An Undervalued Issue in the Era of #PrecisionOncology

The utility of patient reported data in a #gynecologiconcology clinic

The utility of patient reported data in a #gynecologiconcology clinic

Competing Risks in Older #Patients With #Cancer: A Systematic Review of #GeriatricOncology Trials

Competing Risks in Older #Patients With #Cancer: A Systematic Review of #GeriatricOncology Trials

Protocol for a phase III pragmatic stepped wedge cluster randomised controlled trial comparing the effectiveness and cost-effectiveness of screening and guidelines with, versus without, implementation strategies for improving #pain in adults with# cancer attending outpatient #oncology and #palliativecare services: the Stop #Cancer PAIN trial

Protocol for a phase III pragmatic stepped wedge cluster randomised controlled trial comparing the effectiveness and cost-effectiveness of screening and guidelines with, versus without, implementation strategies for improving #pain in adults with# cancer attending outpatient #oncology and #palliativecare services: the Stop #Cancer PAIN trial

#ModernImmuno-#oncology: a new paradigm in #Pathology

#ModernImmuno-#oncology: a new paradigm in #Pathology

Significance of pleural effusion at diagnosis in #pediatricHodgkin#lymphoma: a report from #Children's #Oncology Group protocol AHOD0031

Significance of pleural effusion at diagnosis in #pediatricHodgkin#lymphoma: a report from #Children's #Oncology Group protocol AHOD0031

Whole-Body #MagneticResonance Imaging in the #Oncology Setting: An Overview and Update on Recent Advances

Whole-Body #MagneticResonance Imaging in the #Oncology Setting: An Overview and Update on Recent Advances

Final results of a randomized phase III trial of induction #chemotherapy followed by concurrent #chemoradiotherapy versus concurrent chemoradiotherapy alone in #patients with stage IVA and IVB #nasopharyngeal #carcinoma-#Taiwan Cooperative #Oncology Group (TCOG) 1303 Study

Final results of a randomized phase III trial of induction #chemotherapy followed by concurrent #chemoradiotherapy versus concurrent chemoradiotherapy alone in #patients with stage IVA and IVB #nasopharyngeal #carcinoma-#Taiwan Cooperative #Oncology Group (TCOG) 1303 Study

#ImmuneTherapy in #Oncology: Are we Approaching the Breakthrough?

#ImmuneTherapy in #Oncology: Are we Approaching the Breakthrough?

Immuno-Oncology: A Brief Overview

Immuno-Oncology: A Brief Overview

Challenges in Immuno-Oncology - Possibilities for Optimization

Challenges in Immuno-Oncology - Possibilities for Optimization

Personalized Medicine in the Oncology Clinic: Implementation and Outcomes of the Johns Hopkins Molecular Tumor Board

Personalized Medicine in the Oncology Clinic: Implementation and Outcomes of the Johns Hopkins Molecular Tumor Board

Perspectives on Geriatric Oncology Research presented at the 2018 American Society of Clinical Oncology Annual Meeting

Perspectives on Geriatric Oncology Research presented at the 2018 American Society of Clinical Oncology Annual Meeting

Anal Carcinoma, Version 2.2018, NCCN Clinical Practice Guidelines in Oncology

Anal Carcinoma, Version 2.2018, NCCN Clinical Practice Guidelines in Oncology

Rectal Cancer, Version 2.2018, NCCN Clinical Practice Guidelines in Oncology

Rectal Cancer, Version 2.2018, NCCN Clinical Practice Guidelines in Oncology

ASHP-HOPA guidelines on the roles and responsibilities of the pharmacy technician in ambulatory oncology pharmacy

ASHP-HOPA guidelines on the roles and responsibilities of the pharmacy technician in ambulatory oncology pharmacy

Ludwig Boltzmann Cluster Oncology (LBC ONC): first 10 years and future perspectives

Ludwig Boltzmann Cluster Oncology (LBC ONC): first 10 years and future perspectives

GUROPA survey: genito-urinary radiation oncology prescription attitudes

GUROPA survey: genito-urinary radiation oncology prescription attitudes